If you´d like to book a one way car rental, that is, drop-off your vehicle in another city or state, you must first check with the rental company to see if there are any restrictions in doing so. It's possible to drop-off your vehicle in a location other than the one from where you picked it up so long as the rental company authorizes it beforehand.
Note, though, that dropping off your vehicle in a different location will most likely incur a one-way fee. This fee is calculated proportionately to the distance between pick-up and drop-off locations and will also account for the rental company’s administrative expenses. Make sure you´re aware of the cost before signing your rental agreement.